TGF-ß1 Inhibition of ACE2 Mediated by miRNA Uncovers Novel Mechanism of SARS-CoV-2 Pathogenesis.

Hejenkowska, Ewelina D; Mitash, Nilay; Donovan, Joshua E; Chandra, Anvita; Bertrand, Carol; De Santi, Chiara; Greene, Catherine M; Mu, Fangping; Swiatecka-Urban, Agnieszka

Hejenkowska, Ewelina D; Mitash, Nilay; Donovan, Joshua E; Chandra, Anvita; Bertrand, Carol; De Santi, Chiara; Greene, Catherine M; Mu, Fangping; Swiatecka-Urban, Agnieszka.

Afiliação

Hejenkowska ED; Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.
Mitash N; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Donovan JE; Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.
Chandra A; Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.
Bertrand C; Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
De Santi C; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Greene CM; Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin, Ireland.
Mu F; Center for Research Computing, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Swiatecka-Urban A; Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA.

J Innate Immun ; 15(1): 629-646, 2023.

Article em En | MEDLINE | ID: mdl-37579743

Assuntos

COVID-19; Fibrose Cística; MicroRNAs; Humanos; SARS-CoV-2/genética; SARS-CoV-2/metabolismo; MicroRNAs/genética; Fator de Crescimento Transformador beta1/genética; Fator de Crescimento Transformador beta1/metabolismo; Enzima de Conversão de Angiotensina 2/genética; Enzima de Conversão de Angiotensina 2/metabolismo; Regulador de Condutância Transmembrana em Fibrose Cística/genética; Regulador de Condutância Transmembrana em Fibrose Cística/metabolismo; Pandemias

Palavras-chave

Angiotensin-converting enzyme 2; Cystic fibrosis; Severe acute respiratory syndrome coronavirus 2; TGF-ß1; miRNA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose Cística / MicroRNAs / COVID-19 Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Humans Idioma: En Revista: J Innate Immun Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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