A 1-year pilot study of intralymphatic injections of GAD-alum in individuals with latent autoimmune diabetes in adults (LADA) with signs of high immunity: No safety concerns and resemblance to juvenile type 1 diabetes.

Hals, Ingrid K; Balasuriya, Chandima; Casas, Rosaura; Ludvigsson, Johnny; Björklund, Anneli; Grill, Valdemar

Hals, Ingrid K; Balasuriya, Chandima; Casas, Rosaura; Ludvigsson, Johnny; Björklund, Anneli; Grill, Valdemar.

Afiliação

Hals IK; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Balasuriya C; Department of Endocrinology, Clinic of Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Casas R; Department of Research, Nord-Trøndelag Hospital Trust, Levanger, Norway.
Ludvigsson J; Department of Endocrinology, Clinic of Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Björklund A; Division of Pediatrics, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
Grill V; Division of Pediatrics, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.

Diabetes Obes Metab ; 25(11): 3400-3409, 2023 11.

Article em En | MEDLINE | ID: mdl-37580967

Assuntos

Diabetes Mellitus Tipo 1; Intolerância à Glucose; Glutamato Descarboxilase; Diabetes Autoimune Latente em Adultos; Adulto; Humanos; Pessoa de Meia-Idade; Autoanticorpos; Diabetes Mellitus Tipo 1/terapia; Intolerância à Glucose/tratamento farmacológico; Glutamato Descarboxilase/efeitos adversos; Glutamato Descarboxilase/uso terapêutico; Injeções Intralinfáticas; Diabetes Autoimune Latente em Adultos/tratamento farmacológico; Leucócitos Mononucleares; Projetos Piloto

Palavras-chave

beta-cell function; clinical trial; drug development; insulin secretion; phase I-II study; type 1 diabetes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Intolerância à Glucose / Diabetes Mellitus Tipo 1 / Diabetes Autoimune Latente em Adultos / Glutamato Descarboxilase Tipo de estudo: Clinical_trials / Diagnostic_studies / Guideline Limite: Adult / Humans / Middle aged Idioma: En Revista: Diabetes Obes Metab Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Noruega

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