Multitarget inhibitors/probes that target LRRK2 and AURORA A kinases noncovalently and covalently.
Chem Commun (Camb)
; 59(72): 10789-10792, 2023 Sep 07.
Article
em En
| MEDLINE
| ID: mdl-37594149
ABSTRACT
Herein, we report a salicylaldehyde-based, reversible covalent inhibitor (A2) that possesses moderate cellular activity against AURKA with a prolonged residence time and shows significant non-covalent inhibition towards LRRK2. Our results indicated that this multitarget kinase inhibitor may be used as the starting point for future development of more potent, selective and dual-targeting covalent kinase inhibitors against AURKA and LRRK2 for mitophagy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mitofagia
/
Aurora Quinase A
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China