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In vitro modeling of CD8+ T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40.
Wu, Jennifer E; Manne, Sasikanth; Ngiow, Shin Foong; Baxter, Amy E; Huang, Hua; Freilich, Elizabeth; Clark, Megan L; Lee, Joanna H; Chen, Zeyu; Khan, Omar; Staupe, Ryan P; Huang, Yinghui J; Shi, Junwei; Giles, Josephine R; Wherry, E John.
Afiliação
  • Wu JE; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Manne S; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Ngiow SF; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA.
  • Baxter AE; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Huang H; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Freilich E; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Clark ML; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Lee JH; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA, USA.
  • Chen Z; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Khan O; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Staupe RP; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Huang YJ; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Shi J; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Giles JR; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Wherry EJ; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sci Immunol ; 8(86): eade3369, 2023 08 25.
Article em En | MEDLINE | ID: mdl-37595022
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas / Exaustão das Células T Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Idioma: En Revista: Sci Immunol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas / Exaustão das Células T Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Idioma: En Revista: Sci Immunol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos