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FMRI Complexity Correlates with Tau-PET and Cognitive Decline in Late-Onset and Autosomal Dominant Alzheimer's Disease.
Jann, Kay; Boudreau, Julia; Albrecht, Daniel; Cen, Steven Y; Cabeen, Ryan P; Ringman, John M; Wang, Danny J J.
Afiliação
  • Jann K; Laboratory of Functional MRI Technology (LOFT), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Boudreau J; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Albrecht D; Laboratory of NeuroImaging (LONI), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Cen SY; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Cabeen RP; Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Ringman JM; Laboratory of NeuroImaging (LONI), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Wang DJJ; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
J Alzheimers Dis ; 95(2): 437-451, 2023.
Article em En | MEDLINE | ID: mdl-37599531
ABSTRACT

BACKGROUND:

Neurofibrillary tangle pathology detected with tau-PET correlates closely with neuronal injury and cognitive symptoms in Alzheimer's disease (AD). Complexity of rs-fMRI has been demonstrated to decrease with cognitive decline in AD.

OBJECTIVE:

We hypothesize that the rs-fMRI complexity provides an index for tau-related neuronal injury and cognitive decline in the AD process.

METHODS:

Data was obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI3) and the Estudio de la Enfermedad de Alzheimer en Jalisciences (EEAJ) study. Associations between tau-PET and rs-fMRI complexity were calculated. Potential pathways relating complexity to cognitive function mediated through tau-PET were assessed by path analysis.

RESULTS:

We found significant negative correlations between rs-fMRI complexity and tau-PET in medial temporal lobe of both cohorts, and associations of rs-fMRI complexity with cognitive scores were mediated through tau-PET.

CONCLUSION:

The association of rs-fMRI complexity with tau-PET and cognition, suggests that a reduction in complexity is indicative of tau-related neuropathology and cognitive decline in AD processes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Disfunção Cognitiva Limite: Humans Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Disfunção Cognitiva Limite: Humans Idioma: En Revista: J Alzheimers Dis Assunto da revista: GERIATRIA / NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos