Thiazolide Prodrug Esters and Derived Peptides: Synthesis and Activity.
ACS Bio Med Chem Au
; 3(4): 327-334, 2023 Aug 16.
Article
em En
| MEDLINE
| ID: mdl-37599793
ABSTRACT
Amino acid ester prodrugs of the thiazolides, introduced to improve the pharmacokinetic parameters of the parent drugs, proved to be stable as their salts but were unstable at pH > 5. Although some of the instability was due to simple hydrolysis, we have found that the main end products of the degradation were peptides formed by rearrangement. These peptides were stable solids they maintained significant antiviral activity, and in general, they showed improved pharmacokinetics (better solubility and reduced clearance) compared to the parent thiazolides. We describe the preparation and evaluation of these peptides.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
ACS Bio Med Chem Au
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Reino Unido