Caspase 5 depletion is linked to hyper-inflammatory response and progeroid syndrome.
Geroscience
; 46(2): 2771-2775, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-37603195
ABSTRACT
A progeroid family was found to harbor a pathogenic variant in the CASP5 gene that encodes inflammatory caspase 5. Caspase 5-depleted fibroblasts exhibited hyper-activation of inflammatory cytokines in response to pro-inflammatory stimuli. Long-term intermittent hyper-inflammatory response is likely the cause of the accelerated aging phenotype comprised of earlier onset of common aging diseases, supporting inflammaging as a potential common disease mechanism of progeroid syndromes and possibly normative aging.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Progéria
Limite:
Humans
Idioma:
En
Revista:
Geroscience
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos