Global air pollution exposure and congenital anomalies: an updated systematic review and meta-analysis of epidemiological studies.
Int J Environ Health Res
; 34(5): 2333-2352, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-37610216
ABSTRACT
A systematic review and meta-analysis was conducted to evaluate recent epidemiological evidence on the association of air pollution with congenital anomalies (CAs). Of 11,014 records, 49 were finally included in this meta-analysis. Per 10 µg/m3 increase in air pollutant, PM10 exposure during the 1st month of pregnancy and at the first trimester (T1) was associated with increased overall CAs. Further, exposure to PM10 was associated with congenital heart disease (OR = 1.055, 95% CI 1.035, 1.074) and patent ductus arteriosus (OR = 1.094, 95% CI 1.020, 1.168) at T1, with chromosomal anomalies during the entire pregnancy and with nervous system anomalies when exposure occurred 3 months prior to pregnancy, during the 1st, 2nd months of pregnancy and at T1. Besides, a significant association with overall CAs was observed for a combined exposure of PM10 and SO2 during the 1st month of gestation (OR 1.101, 95% CI 1.023, 1.180). A combined exposure of PM10 and CO was also associated with tetralogy of Fallot during 3-8 weeks of gestation (OR 1.016, 95% CI 1.005, 1.027). No significant associations were observed between PM2.5, NO2, and O3 exposure and CAs.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ozônio
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Poluentes Atmosféricos
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Poluição do Ar
Tipo de estudo:
Systematic_reviews
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Int J Environ Health Res
Assunto da revista:
SAUDE AMBIENTAL
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China