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Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression.
Fu, Ting; Huan, Tao; Rahman, Gibraan; Zhi, Hui; Xu, Zhenjiang; Oh, Tae Gyu; Guo, Jian; Coulter, Sally; Tripathi, Anupriya; Martino, Cameron; McCarville, Justin L; Zhu, Qiyun; Cayabyab, Fritz; Low, Brian; He, Mingxiao; Xing, Shipei; Vargas, Fernando; Yu, Ruth T; Atkins, Annette; Liddle, Christopher; Ayres, Janelle; Raffatellu, Manuela; Dorrestein, Pieter C; Downes, Michael; Knight, Rob; Evans, Ronald M.
Afiliação
  • Fu T; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Huan T; Department of Chemistry, UBC Faculty of Science, Vancouver Campus, Vancouver, BC V6T 1Z4, Canada.
  • Rahman G; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA 92093, USA.
  • Zhi H; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
  • Xu Z; UCSD Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
  • Oh TG; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Guo J; Department of Chemistry, UBC Faculty of Science, Vancouver Campus, Vancouver, BC V6T 1Z4, Canada.
  • Coulter S; Storr Liver Centre, Westmead Institute for Medical Research and Sydney Medical School, University of Sydney, Westmead, NSW 2145, Australia.
  • Tripathi A; UCSD Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
  • Martino C; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; UCSD Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
  • McCarville JL; Molecular and Systems Physiology Laboratory, Gene Expression Laboratory, NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Zhu Q; UCSD Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
  • Cayabyab F; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Low B; Department of Chemistry, UBC Faculty of Science, Vancouver Campus, Vancouver, BC V6T 1Z4, Canada.
  • He M; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Xing S; Department of Chemistry, UBC Faculty of Science, Vancouver Campus, Vancouver, BC V6T 1Z4, Canada.
  • Vargas F; UCSD Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
  • Yu RT; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Atkins A; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Liddle C; Storr Liver Centre, Westmead Institute for Medical Research and Sydney Medical School, University of Sydney, Westmead, NSW 2145, Australia.
  • Ayres J; Molecular and Systems Physiology Laboratory, Gene Expression Laboratory, NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Raffatellu M; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; UCSD Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA; Chiba University-UC San Diego Center for Mucosal Immunity, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla, CA 9
  • Dorrestein PC; UCSD Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA; Department of Engineering, University of California, San Diego, La Jolla, CA 92093, USA; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, Univ
  • Downes M; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Knight R; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; UCSD Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA; D
  • Evans RM; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: evans@salk.edu.
Cell Rep ; 42(8): 112997, 2023 08 29.
Article em En | MEDLINE | ID: mdl-37611587
ABSTRACT
Colorectal cancer (CRC) is driven by genomic alterations in concert with dietary influences, with the gut microbiome implicated as an effector in disease development and progression. While meta-analyses have provided mechanistic insight into patients with CRC, study heterogeneity has limited causal associations. Using multi-omics studies on genetically controlled cohorts of mice, we identify diet as the major driver of microbial and metabolomic differences, with reductions in α diversity and widespread changes in cecal metabolites seen in high-fat diet (HFD)-fed mice. In addition, non-classic amino acid conjugation of the bile acid cholic acid (AA-CA) increased with HFD. We show that AA-CAs impact intestinal stem cell growth and demonstrate that Ileibacterium valens and Ruminococcus gnavus are able to synthesize these AA-CAs. This multi-omics dataset implicates diet-induced shifts in the microbiome and the metabolome in disease progression and has potential utility in future diagnostic and therapeutic developments.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Microbiota / Microbioma Gastrointestinal Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Microbiota / Microbioma Gastrointestinal Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos