A new secondary metabolite from the marine-derived fungus Phomopsis lithocarpus FS508.
J Asian Nat Prod Res
; 26(4): 534-540, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-37639617
ABSTRACT
Based on the One Strain-Many Compounds (OSMAC) strategy, the secondary metabolites of Phomopsis lithocarpus FS508 were investigated. As a result, a new secondary metabolite, 4-methoxy-3-[4-(acetyloxy)-3-methyl-2-butenyl]benzoic acid (1) as well as eleven known compounds were isolated from the fermentation product of the strain FS508. Their structures were determined by NMR, IR, UV, and MS spectroscopic data analyses. All the isolated compounds were evaluated for cytotoxic and anti-inflammatory activities. Among them, compounds 3 and 9 displayed potent cytotoxicity against HepG-2 cell line, and compounds 2, 3 and 12 showed significant anti-inflammatory activities.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Antineoplásicos
Idioma:
En
Revista:
J Asian Nat Prod Res
Assunto da revista:
BOTANICA
/
QUIMICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China