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Predictive factors for decreased baseline quality of life in patients with sinonasal malignancies.
Fleseriu, Cara M; Beswick, Daniel M; Maoz, Sabrina L; Hwang, Peter H; Choby, Garret; Kuan, Edward C; Chan, Erik P; Adappa, Nithin D; Geltzeiler, Mathew; Getz, Anne E; Humphries, Ian M; Le, Christopher H; Abuzeid, Waleed M; Chang, Eugene H; Jafari, Aria; Kingdom, Todd T; Kohanski, Michael A; Lee, Jivianne K; Nabavizadeh, Seyed A; Nayak, Jayakar V; Palmer, James N; Patel, Zara M; Pinheiro-Neto, Carlos D; Resnick, Adam C; Smith, Timothy L; Snyderman, Carl H; St John, Maie A; Storm, Jay; Suh, Jeffrey D; Wang, Marilene B; Wang, Eric W.
Afiliação
  • Fleseriu CM; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Beswick DM; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Maoz SL; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Hwang PH; Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
  • Choby G; Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.
  • Kuan EC; Department of Otolaryngology-Head and Neck Surgery, University of California Irvine, Orange, California, USA.
  • Chan EP; Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
  • Adappa ND; Department of Otolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Geltzeiler M; Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.
  • Getz AE; Department of Otolaryngology-Head and Neck Surgery, University of Colorado, Aurora, Colorado, USA.
  • Humphries IM; Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
  • Le CH; Department of Otolaryngology-Head and Neck Surgery, University of Arizona, Tucson, Arizona, USA.
  • Abuzeid WM; Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
  • Chang EH; Department of Otolaryngology-Head and Neck Surgery, University of Arizona, Tucson, Arizona, USA.
  • Jafari A; Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
  • Kingdom TT; Department of Otolaryngology-Head and Neck Surgery, University of Colorado, Aurora, Colorado, USA.
  • Kohanski MA; Department of Otolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Lee JK; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Nabavizadeh SA; Department of Otolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Nayak JV; Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
  • Palmer JN; Department of Otolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Patel ZM; Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
  • Pinheiro-Neto CD; Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.
  • Resnick AC; Center for Data Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Smith TL; Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon, USA.
  • Snyderman CH; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • St John MA; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Storm J; Center for Data Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Suh JD; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Wang MB; Department of Otolaryngology-Head and Neck Surgery, University of California Los Angeles, Los Angeles, California, USA.
  • Wang EW; Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Int Forum Allergy Rhinol ; 14(4): 775-785, 2024 Apr.
Article em En | MEDLINE | ID: mdl-37646428
ABSTRACT

BACKGROUND:

The impact of sinonasal malignancies (SNMs) on quality of life (QOL) at presentation is poorly understood. The Sinonasal Outcome Test (SNOT-22) and University of Washington Quality of Life (UWQOL) are validated QOL instruments with distinctive subdomains. This study aims to identify factors impacting pretreatment QOL in SNM patients to personalize multidisciplinary management and counseling.

METHODS:

Patients with previously untreated SNMs were prospectively enrolled (2015-2022) in a multicenter observational study. Baseline pretreatment QOL instruments (SNOT-22, UWQOL) were obtained along with demographics, comorbidities, histopathology/staging, tumor involvement, and symptoms. Multivariable regression models identified factors associated with reduced baseline QOL.

RESULTS:

Among 204 patients, presenting baseline QOL was significantly reduced. Multivariable regression showed worse total SNOT-22 QOL in patients with skull base erosion (p = 0.02). SNOT-rhinologic QOL was worse in women (p = 0.009), patients with epistaxis (p = 0.036), and industrial exposure (p = 0.005). SNOT extranasal QOL was worse in patients with industrial exposure (p = 0.016); worse SNOT ear/facial QOL if perineural invasion (PNI) (p = 0.027). Squamous cell carcinoma pathology (p = 0.037), palate involvement (p = 0.012), and pain (p = 0.017) were associated with worse SNOT sleep QOL scores. SNOT psychological subdomain scores were significantly worse in patients with palate lesions (p = 0.022), skull base erosion (p = 0.025), and T1 staging (p = 0.023). Low QOL was more likely in the presence of PNI on UW health (p = 0.019) and orbital erosion on UW overall (p = 0.03). UW social QOL was worse if palatal involvement (p = 0.023) or PNI (p = 0.005).

CONCLUSIONS:

Our findings demonstrate a negative impact on baseline QOL in patients with SNMs and suggest sex-specific and symptom-related lower QOL scores, with minimal histopathology association. Anatomical tumor involvement may be more reflective of QOL than T-staging, as orbital and skull base erosion, PNI, and palate lesions are significantly associated with reduced baseline QOL.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rinite / Neoplasias da Base do Crânio Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Int Forum Allergy Rhinol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rinite / Neoplasias da Base do Crânio Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: Int Forum Allergy Rhinol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos