Synthesis and Preclinical Evaluation of [<i>Methylpiperazine</i>-<sup>11</sup>C]brigatinib as a PET Tracer Targeting Both Mutated Epidermal Growth Factor Receptor and Anaplastic Lymphoma Kinase.

Högnäsbacka, Antonia A; Poot, Alex J; Kooijman, Esther; Schuit, Robert C; Schreurs, Maxime; Verlaan, Mariska; Beaino, Wissam; van Dongen, Guus A M S; Vugts, Danielle J; Windhorst, Albert D

Synthesis and Preclinical Evaluation of [Methylpiperazine-¹¹C]brigatinib as a PET Tracer Targeting Both Mutated Epidermal Growth Factor Receptor and Anaplastic Lymphoma Kinase.

Högnäsbacka, Antonia A; Poot, Alex J; Kooijman, Esther; Schuit, Robert C; Schreurs, Maxime; Verlaan, Mariska; Beaino, Wissam; van Dongen, Guus A M S; Vugts, Danielle J; Windhorst, Albert D.

Afiliação

Högnäsbacka AA; Department of Radiology & Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands.
Poot AJ; Biomarkers & Imaging, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Kooijman E; Department of Radiology & Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands.
Schuit RC; Biomarkers & Imaging, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Schreurs M; Department of Radiology & Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands.
Verlaan M; Biomarkers & Imaging, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Beaino W; Department of Radiology & Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands.
van Dongen GAMS; Biomarkers & Imaging, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Vugts DJ; Department of Radiology & Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands.
Windhorst AD; Biomarkers & Imaging, Cancer Center Amsterdam, Amsterdam, The Netherlands.

J Med Chem ; 66(17): 12130-12140, 2023 09 14.

Article em En | MEDLINE | ID: mdl-37647220

Assuntos

Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Humanos; Feminino; Animais; Camundongos; Quinase do Linfoma Anaplásico; Carcinoma Pulmonar de Células não Pequenas/diagnóstico por imagem; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Neoplasias Pulmonares/tratamento farmacológico; Receptores ErbB/genética; Tomografia por Emissão de Pósitrons

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Limite: Animals / Female / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Holanda

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