Calmodulin mutations affecting Gly114 impair binding to the Na<sub>V</sub>1.5 IQ-domain.

Brohus, Malene; Busuioc, Ana-Octavia; Wimmer, Reinhard; Nyegaard, Mette; Overgaard, Michael Toft

Calmodulin mutations affecting Gly114 impair binding to the Na_V1.5 IQ-domain.

Brohus, Malene; Busuioc, Ana-Octavia; Wimmer, Reinhard; Nyegaard, Mette; Overgaard, Michael Toft.

Afiliação

Brohus M; Department of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.
Busuioc AO; Department of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.
Wimmer R; Department of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.
Nyegaard M; Department of Health Science and Technology, Aalborg University, Gistrup, Denmark.
Overgaard MT; Department of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.

Front Pharmacol ; 14: 1210140, 2023.

Article em En | MEDLINE | ID: mdl-37663247

Palavras-chave

NaV1.5; SCN5A; arrhythmogenic; calmodulin; calmodulin target binding; calmodulinopathy; cardiac ion-channel regulation; experimental variant interpretation

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Front Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Dinamarca

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Front Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Dinamarca