Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC-MS/MS and Their Modulatory Effects on Amyloid ß Aggregation.

Taniwa, Kota; Murakami, Kazuma; Sakaguchi, Yoshiki; Izuo, Naotaka; Hanaki, Mizuho; Sampa, Nobuaki; Kume, Toshiaki; Shimizu, Takahiko; Irie, Kazuhiro

Taniwa, Kota; Murakami, Kazuma; Sakaguchi, Yoshiki; Izuo, Naotaka; Hanaki, Mizuho; Sampa, Nobuaki; Kume, Toshiaki; Shimizu, Takahiko; Irie, Kazuhiro.

Afiliação

Taniwa K; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Murakami K; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Sakaguchi Y; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Izuo N; Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Hanaki M; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Sampa N; Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Kume T; Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Shimizu T; Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Irie K; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

J Agric Food Chem ; 71(39): 14289-14299, 2023 Oct 04.

Article em En | MEDLINE | ID: mdl-37702279

Assuntos

Doença de Alzheimer; Chalconas; Ingredientes de Alimentos; Camundongos; Animais; Peptídeos beta-Amiloides/metabolismo; Flavonoides; Espectrometria de Massas em Tandem; Cromatografia Líquida; Doença de Alzheimer/metabolismo; Sulfatos; Fragmentos de Peptídeos/química

Palavras-chave

Alzheimer's disease; UPLC−MS/MS; aggregation; amyloid ß-protein; chalcone; flavonoid; glucuronidation; metabolite; oligomer; sulfation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Chalconas / Doença de Alzheimer / Ingredientes de Alimentos Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: J Agric Food Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão

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