Interplay Between Antimicrobial Resistance and Global Environmental Change.
Annu Rev Genet
; 57: 275-296, 2023 11 27.
Article
em En
| MEDLINE
| ID: mdl-37708420
ABSTRACT
Antibiotic resistance genes predate the therapeutic uses of antibiotics. However, the current antimicrobial resistance crisis stems from our extensive use of antibiotics and the generation of environmental stressors that impose new selective pressure on microbes and drive the evolution of resistant pathogens that now threaten human health. Similar to climate change, this global threat results from human activities that change habitats and natural microbiomes, which in turn interact with human-associated ecosystems and lead to adverse impacts on human health. Human activities that alter our planet at global scales exacerbate the current resistance crisis and exemplify our central role in large-scale changes in which we are both protagonists and architects of our success but also casualties of unanticipated collateral outcomes. As cognizant participants in this ongoing planetary experiment, we are driven to understand and find strategies to curb the ongoing crises of resistance and climate change.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Farmacorresistência Bacteriana
/
Microbiota
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Genet
Ano de publicação:
2023
Tipo de documento:
Article