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Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling.
Vales, Serena; Kryukova, Jhanna; Chandra, Soumyanetra; Smagurauskaite, Gintare; Payne, Megan; Clark, Charlie J; Hafner, Katrin; Mburu, Philomena; Denisov, Stepan; Davies, Graham; Outeiral, Carlos; Deane, Charlotte M; Morris, Garrett M; Bhattacharya, Shoumo.
Afiliação
  • Vales S; Wellcome Centre for Human Genetics and RDM Cardiovascular Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
  • Kryukova J; Wellcome Centre for Human Genetics and RDM Cardiovascular Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
  • Chandra S; Wellcome Centre for Human Genetics and RDM Cardiovascular Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
  • Smagurauskaite G; Wellcome Centre for Human Genetics and RDM Cardiovascular Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
  • Payne M; Wellcome Centre for Human Genetics and RDM Cardiovascular Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
  • Clark CJ; Wellcome Centre for Human Genetics and RDM Cardiovascular Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
  • Hafner K; Wellcome Centre for Human Genetics and RDM Cardiovascular Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
  • Mburu P; Wellcome Centre for Human Genetics and RDM Cardiovascular Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
  • Denisov S; Wellcome Centre for Human Genetics and RDM Cardiovascular Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
  • Davies G; Wellcome Centre for Human Genetics and RDM Cardiovascular Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
  • Outeiral C; Department of Statistics, University of Oxford, 24-29 St Giles, Oxford, OX1 3LB, UK.
  • Deane CM; Department of Statistics, University of Oxford, 24-29 St Giles, Oxford, OX1 3LB, UK.
  • Morris GM; Department of Statistics, University of Oxford, 24-29 St Giles, Oxford, OX1 3LB, UK.
  • Bhattacharya S; Wellcome Centre for Human Genetics and RDM Cardiovascular Medicine, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK. shoumo.bhattacharya@cardiov.ox.ac.uk.
Nat Commun ; 14(1): 5763, 2023 09 16.
Article em En | MEDLINE | ID: mdl-37717048
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bacteriófagos / Quimiocinas Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bacteriófagos / Quimiocinas Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido