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Blood Pressure Outcomes in NICU-Admitted Infants with Neonatal Hypertension: A Pediatric Nephrology Research Consortium Study.
Xiao, Nianzhou; Starr, Michelle; Stolfi, Adrienne; Hamdani, Gilad; Hashmat, Shireen; Kiessling, Stefan G; Sethna, Christina; Kallash, Mahmoud; Matloff, Robyn; Woroniecki, Robert; Sanderson, Keia; Yamaguchi, Ikuyo; Cha, Stephen D; Semanik, Michael G; Chanchlani, Rahul; Flynn, Joseph T; Mitsnefes, Mark.
Afiliação
  • Xiao N; Department of Nephrology, Valley Children's Healthcare, Madera, CA. Electronic address: nxiao@valleychildrens.org.
  • Starr M; Riley Hospital for Children and Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN; Division of Nephrology, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA.
  • Stolfi A; Department of Pediatrics, Wright State University, Dayton, OH.
  • Hamdani G; Nephrology and Hypertension Institute, Schneider's Children Medical Center, Petah Tikva, Israel.
  • Hashmat S; Department of Pediatrics, University of Chicago, Chicago, IL.
  • Kiessling SG; Division of Pediatric Nephrology, Kentucky Children's Hospital, University of Kentucky, Lexington, KY.
  • Sethna C; Division of Pediatric Nephrology, Cohen Children's Medical Center, Zucker School of Medicine at Hofstra/Northwell, Queens, NY.
  • Kallash M; Division of Nephrology, Nationwide Children's Hospital, Columbus, OH.
  • Matloff R; Division of Pediatric Nephrology, Connecticut Children's Hospital, University of Connecticut School of Medicine, Hartford, CT.
  • Woroniecki R; Division of Pediatric Nephrology and Hypertension, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY.
  • Sanderson K; Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill, NC.
  • Yamaguchi I; Division of Nephrology and Hypertension, Department of Pediatrics, Oklahoma Children's Hospital at University of Oklahoma Health Sciences Center, Oklahoma, OK.
  • Cha SD; Division of Nephrology, Akron Children's Hospital, Akron, OH.
  • Semanik MG; Division of Nephrology, Department of Pediatrics, University of Wisconsin at Madison, Madison, WI.
  • Chanchlani R; Division of Pediatric Nephrology, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
  • Flynn JT; Division of Nephrology, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA.
  • Mitsnefes M; Division of Nephrology and Hypertension, Cincinnati Children's Medical Center, Cincinnati, OH.
J Pediatr ; 264: 113765, 2024 Jan.
Article em En | MEDLINE | ID: mdl-37778410
ABSTRACT

OBJECTIVE:

To describe the blood pressure outcomes of infants admitted to the neonatal intensive care unit (NICU) with idiopathic (nonsecondary) hypertension (HTN) who were discharged on antihypertensive therapy. STUDY

DESIGN:

Retrospective, multicenter study of 14 centers within the Pediatric Nephrology Research Consortium. We included all infants with a diagnosis of idiopathic HTN discharged from the NICU on antihypertensive treatment. The primary outcome was time to discontinuation of antihypertensive therapy, grouped into (≤6 months, >6 months to 1 year, and >1 year). Comparisons between groups were made with χ2 tests, Fisher's exact tests, and ANOVA.

RESULTS:

Data from 118 infants (66% male) were included. Calcium channel blockers were the most prescribed class of antihypertensives (56%) in the cohort. The percentages remaining on antihypertensives after NICU discharge were 60% at 6 months, 26% at 1 year, and 7% at 2 years. Antenatal steroid treatment was associated with decreased likelihood of antihypertensive therapy >1 year after discharge.

CONCLUSIONS:

This multicenter study reports that most infants admitted to the NICU diagnosed with idiopathic HTN will discontinue antihypertensive treatment by 2 years after NICU discharge. These data provide important insights into the outcome of neonatal HTN, but should be confirmed prospectively.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hipertensão / Doenças do Recém-Nascido / Nefrologia Tipo de estudo: Clinical_trials Limite: Child / Female / Humans / Infant / Male / Newborn / Pregnancy Idioma: En Revista: J Pediatr Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hipertensão / Doenças do Recém-Nascido / Nefrologia Tipo de estudo: Clinical_trials Limite: Child / Female / Humans / Infant / Male / Newborn / Pregnancy Idioma: En Revista: J Pediatr Ano de publicação: 2024 Tipo de documento: Article