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Neuregulin-1ß Improves Uremic Cardiomyopathy and Renal Dysfunction in Rats.
Sárközy, Márta; Watzinger, Simon; Kovács, Zsuzsanna Z A; Acar, Eylem; Márványkövi, Fanni; Szucs, Gergo; Lauber, Gülsüm Yilmaz; Galla, Zsolt; Siska, Andrea; Földesi, Imre; Fintha, Attila; Kriston, András; Kovács, Ferenc; Horváth, Péter; Kovári, Bence; Cserni, Gábor; Krenács, Tibor; Szabó, Petra Lujza; Szabó, Gábor Tamás; Monostori, Péter; Zins, Karin; Abraham, Dietmar; Csont, Tamás; Pokreisz, Peter; Podesser, Bruno K; Kiss, Attila.
Afiliação
  • Sárközy M; MEDICS Research Group, Department of Biochemistry, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
  • Watzinger S; Interdisciplinary Center of Excellence, University of Szeged, Szeged, Hungary.
  • Kovács ZZA; Ludwig Boltzmann Institute for Cardiovascular Research at Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, Austria.
  • Acar E; MEDICS Research Group, Department of Biochemistry, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
  • Márványkövi F; Interdisciplinary Center of Excellence, University of Szeged, Szeged, Hungary.
  • Szucs G; Ludwig Boltzmann Institute for Cardiovascular Research at Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, Austria.
  • Lauber GY; MEDICS Research Group, Department of Biochemistry, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
  • Galla Z; Interdisciplinary Center of Excellence, University of Szeged, Szeged, Hungary.
  • Siska A; MEDICS Research Group, Department of Biochemistry, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
  • Földesi I; Interdisciplinary Center of Excellence, University of Szeged, Szeged, Hungary.
  • Fintha A; Ludwig Boltzmann Institute for Cardiovascular Research at Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, Austria.
  • Kriston A; Metabolic and Newborn Screening Laboratory, Department of Pediatrics, Albert Szent-Györgyi Medical School, University of Szeged, Hungary.
  • Kovács F; Department of Laboratory Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
  • Horváth P; Department of Laboratory Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
  • Kovári B; Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
  • Cserni G; Synthetic and Systems Biology Unit, Biological Research Centre, Eötvös Loránd Research Network, Szeged, Hungary.
  • Krenács T; Single-Cell Technologies Ltd, Szeged, Hungary.
  • Szabó PL; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Szabó GT; Synthetic and Systems Biology Unit, Biological Research Centre, Eötvös Loránd Research Network, Szeged, Hungary.
  • Monostori P; Single-Cell Technologies Ltd, Szeged, Hungary.
  • Zins K; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Abraham D; Synthetic and Systems Biology Unit, Biological Research Centre, Eötvös Loránd Research Network, Szeged, Hungary.
  • Csont T; Single-Cell Technologies Ltd, Szeged, Hungary.
  • Pokreisz P; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Podesser BK; Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
  • Kiss A; Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
JACC Basic Transl Sci ; 8(9): 1160-1176, 2023 Sep.
Article em En | MEDLINE | ID: mdl-37791301
ABSTRACT
Chronic kidney disease is a global health problem affecting 10% to 12% of the population. Uremic cardiomyopathy is often characterized by left ventricular hypertrophy, fibrosis, and diastolic dysfunction. Dysregulation of neuregulin-1ß signaling in the heart is a known contributor to heart failure. The systemically administered recombinant human neuregulin-1ß for 10 days in our 5/6 nephrectomy-induced model of chronic kidney disease alleviated the progression of uremic cardiomyopathy and kidney dysfunction in type 4 cardiorenal syndrome. The currently presented positive preclinical data warrant clinical studies to confirm the beneficial effects of recombinant human neuregulin-1ß in patients with chronic kidney disease.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Hungria
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Hungria