Prognostic Impact of Blood Lipid Profile in Patients With Advanced Solid Tumors Treated With Immune Checkpoint Inhibitors: A Multicenter Cohort Study.
Oncologist
; 29(3): e372-e381, 2024 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-37796838
ABSTRACT
BACKGROUND:
Specific components of lipid profile seem to differently impact on immune activity against cancer and unraveling their prognostic role in patients with solid cancer treated with immune checkpoint inhibitors (ICIs) is needed. MATERIALS ANDMETHODS:
We retrospectively collected baseline clinicopathological characteristics including circulating lipid profile (total cholesterol [TC], triglycerides [TG], low-density lipoproteins [LDL], high-density lipoproteins [HDL]) of patients with consecutive solid cancer treated with ICIs, and we investigated their role in predicting clinical outcomes.RESULTS:
At a median follow-up of 32.9 months, among 430 enrolled patients, those with TCâ ≥â 200 mg/dl showed longer median progression-free survival (mPFS; 6.6 vs. 4.7 months, Pâ =â .4), although not reaching statistical significance, and significantly longer median overall survival (mOS; 19.4 vs. 10.8 months, Pâ =â .02) compared to those with TCâ <â 200 mg/dl. Conversely, patients with TG ≥150 mg/dl displayed shorter PFS (3.4 vs. 5.1 months, Pâ =â .02) and OS (7.1 vs. 12.9 months, Pâ =â .009) compared to those with TG <150 mg/dl. TC and TG were then combined in a "LIPID score" identifying three subgroups good-risk (GR) (TC ≥200 mg/dl and TG <150 mg/dl), intermediate-risk (IR) (TC <200 mg/dl and TG <150 mg/dl or TC ≥200 mg/dl and TG ≥150 mg/dl) and poor-risk (PR) (TC <200 mg/dl and TG ≥150 mg/dl). The mPFS of GR, IR, and PR groups was 7.8, 4.3, and 2.5 months, respectively (Pâ =â .005); mOS of GR, IR, and PR was 20.4, 12.4, and 5.3 months, respectively (Pâ <â .001). At multivariable analysis, the PR profile represented an independent poor prognostic factor for both PFS and OS.CONCLUSIONS:
We developed a lipid score that defined subgroups of patients with cancer who differently benefit from ICIs. Further mechanistic insights are warranted to clarify the prognostic and predictive role of lipid profile components in patients treated with ICIs.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Checkpoint Imunológico
/
Neoplasias
Tipo de estudo:
Clinical_trials
/
Etiology_studies
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Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Oncologist
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Itália