N-acetylneuraminic acid modulates SQSTM1/p62 sialyation-mediated ubiquitination degradation contributing to vascular endothelium dysfunction in experimental atherosclerosis mice.

Chen, Le; Qiu, Hongmei; Chen, Qingqiu; Xiang, Peng; Lei, Jin; Zhang, Jun; Lu, Yining; Wang, Xianmin; Wu, Shengde; Yu, Chao; Ma, Limei

Chen, Le; Qiu, Hongmei; Chen, Qingqiu; Xiang, Peng; Lei, Jin; Zhang, Jun; Lu, Yining; Wang, Xianmin; Wu, Shengde; Yu, Chao; Ma, Limei.

Afiliação

Chen L; College of Pharmacy, Chongqing Medical University, Chongqing, China.
Qiu H; Chongqing Key Laboratory for Pharmaceutical Metabolism Research, Chongqing, China.
Chen Q; College of Pharmacy, Chongqing Medical University, Chongqing, China.
Xiang P; Chongqing Key Laboratory for Pharmaceutical Metabolism Research, Chongqing, China.
Lei J; College of Pharmacy, Chongqing Medical University, Chongqing, China.
Zhang J; Chongqing Key Laboratory for Pharmaceutical Metabolism Research, Chongqing, China.
Lu Y; College of Pharmacy, Chongqing Medical University, Chongqing, China.
Wang X; Chongqing Key Laboratory for Pharmaceutical Metabolism Research, Chongqing, China.
Wu S; Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, China.
Yu C; Chongqing Key Laboratory for Pharmaceutical Metabolism Research, Chongqing, China.
Ma L; College of Pharmacy, Chongqing Medical University, Chongqing, China.

IUBMB Life ; 76(3): 161-178, 2024 Mar.

Article em En | MEDLINE | ID: mdl-37818680

Assuntos

Aterosclerose; Ácido N-Acetilneuramínico; Humanos; Camundongos; Animais; Ácido N-Acetilneuramínico/metabolismo; Ácido N-Acetilneuramínico/farmacologia; Proteína Sequestossoma-1/genética; Proteína Sequestossoma-1/metabolismo; Células Endoteliais/metabolismo; Endotélio Vascular/metabolismo; Ubiquitinação; Ubiquitina/metabolismo; Aterosclerose/genética; Aterosclerose/metabolismo; Apolipoproteínas E/metabolismo; Apolipoproteínas E/farmacologia; Autofagia

Palavras-chave

Neu5Ac; SQSTM1/p62; atherosclerosis; endothelial injury; sialylation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido N-Acetilneuramínico / Aterosclerose Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: IUBMB Life Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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