Rifampicin-induced ER stress and excessive cytoplasmic vacuolization instigate hepatotoxicity via alternate programmed cell death paraptosis in vitro and in vivo.

Kainat, K M; Ansari, Mohammad Imran; Bano, Nuzhat; Jagdale, Pankaj Ramji; Ayanur, Anjaneya; Kumar, Mahadeo; Sharma, Pradeep Kumar

Kainat, K M; Ansari, Mohammad Imran; Bano, Nuzhat; Jagdale, Pankaj Ramji; Ayanur, Anjaneya; Kumar, Mahadeo; Sharma, Pradeep Kumar.

Afiliação

Kainat KM; Food Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Ansari MI; Food Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Bano N; Food Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Jagdale PR; Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India.
Ayanur A; Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India.
Kumar M; Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India.
Sharma PK; Food Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: pradeep.sharma@iitr.res.in.

Life Sci ; 333: 122164, 2023 Nov 15.

Article em En | MEDLINE | ID: mdl-37827230

Assuntos

Doença Hepática Induzida por Substâncias e Drogas; Rifampina; Masculino; Humanos; Ratos; Animais; Rifampina/toxicidade; Espécies Reativas de Oxigênio/metabolismo; Ratos Wistar; Apoptose; Estresse do Retículo Endoplasmático; Doença Hepática Induzida por Substâncias e Drogas/etiologia

Palavras-chave

Cycloheximide; Drug-induced liver injury; Endoplasmic reticulum stress; Hepatotoxicity; Paraptosis; Rifampicin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rifampina / Doença Hepática Induzida por Substâncias e Drogas Limite: Animals / Humans / Male Idioma: En Revista: Life Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Índia

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