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Lateralized grey matter volume changes in adolescents versus adults with major depression: SDM-PSI meta-analysis.
Zhang, Emily; Hauson, Alexander O; Pollard, Anna A; Meis, Benjamin; Lackey, Nicholas S; Carson, Bryce; Khayat, Sarah; Fortea, Lydia; Radua, Joaquim.
Afiliação
  • Zhang E; California School of Professional Psychology, Clinical Psychology Ph.D. Program, San Diego, CA, United States of America; Institute of Brain Research and Integrated Neuropsychological Services (iBRAINs.org), San Diego, CA, United States of America.
  • Hauson AO; California School of Professional Psychology, Clinical Psychology Ph.D. Program, San Diego, CA, United States of America; Institute of Brain Research and Integrated Neuropsychological Services (iBRAINs.org), San Diego, CA, United States of America; Department of Psychiatry, University of California
  • Pollard AA; California School of Professional Psychology, Clinical Psychology Ph.D. Program, San Diego, CA, United States of America; Institute of Brain Research and Integrated Neuropsychological Services (iBRAINs.org), San Diego, CA, United States of America.
  • Meis B; California School of Professional Psychology, Clinical Psychology Ph.D. Program, San Diego, CA, United States of America; Institute of Brain Research and Integrated Neuropsychological Services (iBRAINs.org), San Diego, CA, United States of America.
  • Lackey NS; California School of Professional Psychology, Clinical Psychology Ph.D. Program, San Diego, CA, United States of America; Institute of Brain Research and Integrated Neuropsychological Services (iBRAINs.org), San Diego, CA, United States of America.
  • Carson B; California School of Professional Psychology, Clinical Psychology Ph.D. Program, San Diego, CA, United States of America; Institute of Brain Research and Integrated Neuropsychological Services (iBRAINs.org), San Diego, CA, United States of America.
  • Khayat S; Institute of Brain Research and Integrated Neuropsychological Services (iBRAINs.org), San Diego, CA, United States of America.
  • Fortea L; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, University of Barcelona, Barcelona, Spain.
  • Radua J; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Medicine, University of Barcelona, Barcelona, Spain; Department of Clinical Neuroscie
Psychiatry Res Neuroimaging ; 335: 111691, 2023 10.
Article em En | MEDLINE | ID: mdl-37837793
The current study is the first meta-analysis to examine grey matter volume (GMV) changes in adolescents and across the lifespan in major depressive disorder (MDD). Seed-based d mapping-with permutation of subject images (SDM-PSI) has advantages over previous coordinate-based meta-analytical methods (CBMA), such as reducing bias (via the MetaNSUE algorithm) and including non-statistically significant unreported effects. SDM-PSI was used to analyze 105 whole-brain GMV voxel-based morphometry (VBM) studies comparing 6,530 individuals with MDD versus 6,821 age-matched healthy controls (HC). A laterality effect was observed in which adults with MDD showed lower GMV than adult HC in left fronto-temporo-parietal structures (superior temporal gyrus, insula, Rolandic operculum, and inferior frontal gyrus). However, these abnormalities were not statistically significant for adolescent MDD versus adolescent HC. Instead, adolescent MDD showed lower GMV than adult MDD in right temporo-parietal structures (angular gyrus and middle temporal gyrus). These regional differences may be used as potential biomarkers to predict and monitor treatment outcomes as well as to choose the most effective treatments in adolescents versus adults. Finally, due to the paucity of youth, older adult, and longitudinal studies, future studies should attempt to replicate these GMV findings and examine whether they correlate with treatment response and illness severity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior / Substância Cinzenta Tipo de estudo: Systematic_reviews Limite: Adolescent / Aged / Humans Idioma: En Revista: Psychiatry Res Neuroimaging Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior / Substância Cinzenta Tipo de estudo: Systematic_reviews Limite: Adolescent / Aged / Humans Idioma: En Revista: Psychiatry Res Neuroimaging Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos