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Physiology-informed toxicokinetic model for the zebrafish embryo test developed for bisphenols.
Chelcea, Ioana; Vogs, Carolina; Hamers, Timo; Koekkoek, Jacco; Legradi, Jessica; Sapounidou, Maria; Örn, Stefan; Andersson, Patrik L.
Afiliação
  • Chelcea I; Department of Chemistry, Umeå University, SE-901 87, Umeå, Sweden.
  • Vogs C; Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Box 7028, SE-75007, Uppsala, Sweden; Institute of Environmental Medicine, Karolinska Institutet, SE-171 65, Solna, Sweden.
  • Hamers T; Amsterdam Institute for Life and Environment (A-LIFE), Vrije Universiteit Amsterdam, 1081, HV Amsterdam, the Netherlands.
  • Koekkoek J; Amsterdam Institute for Life and Environment (A-LIFE), Vrije Universiteit Amsterdam, 1081, HV Amsterdam, the Netherlands.
  • Legradi J; Amsterdam Institute for Life and Environment (A-LIFE), Vrije Universiteit Amsterdam, 1081, HV Amsterdam, the Netherlands.
  • Sapounidou M; Department of Chemistry, Umeå University, SE-901 87, Umeå, Sweden.
  • Örn S; Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Box 7028, SE-75007, Uppsala, Sweden.
  • Andersson PL; Department of Chemistry, Umeå University, SE-901 87, Umeå, Sweden. Electronic address: patrik.andersson@umu.se.
Chemosphere ; 345: 140399, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37839743
Zebrafish embryos (ZFE) is a widely used model organism, employed in various research fields including toxicology to assess e.g., developmental toxicity and endocrine disruption. Variation in effects between chemicals are difficult to compare using nominal dose as toxicokinetic properties may vary. Toxicokinetic (TK) modeling is a means to estimate internal exposure concentration or dose at target and to enable extrapolation between experimental conditions and species, thereby improving hazard assessment of potential pollutants. In this study we advance currently existing TK models for ZFE with physiological ZFE parameters and novel experimental bisphenol data, a class of chemicals with suspected endocrine activity. We developed a five-compartment model consisting of water, plastic, chorion, yolk sack and embryo in which surface area and volume changes as well as the processes of biotransformation and blood circulation influence mass fluxes. For model training and validation, we measured internal concentrations in ZFE exposed individually to BPA, bisphenol AF (BPAF) and Z (BPZ). Bayesian inference was applied for parameter calibration based on the training data set of BPZ. The calibrated TK model predicted internal ZFE concentrations of the majority of external test data within a 5-fold error and half of the data within a 2-fold error for bisphenols A, AF, F, and tetrabromo bisphenol A (TBBPA). We used the developed model to rank the hazard of seven bisphenols based on predicted internal concentrations and measured in vitro estrogenicity. This ranking indicated a higher hazard for BPAF, BPZ, bisphenol B and C (BPB, BPC) than for BPA.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Poluentes Ambientais Limite: Animals Idioma: En Revista: Chemosphere Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suécia

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Poluentes Ambientais Limite: Animals Idioma: En Revista: Chemosphere Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suécia