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Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2.
Liao, Yi; Remsing Rix, Lily L; Li, Xueli; Fang, Bin; Izumi, Victoria; Welsh, Eric A; Monastyrskyi, Andrii; Haura, Eric B; Koomen, John M; Doebele, Robert C; Rix, Uwe.
Afiliação
  • Liao Y; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Remsing Rix LL; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Li X; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Fang B; Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Izumi V; Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Welsh EA; Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Monastyrskyi A; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Department of Oncologic Sciences, University of South Florida, Tampa, FL 33620, USA.
  • Haura EB; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Koomen JM; Department of Oncologic Sciences, University of South Florida, Tampa, FL 33620, USA; Department of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
  • Doebele RC; Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Rix U; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Department of Oncologic Sciences, University of South Florida, Tampa, FL 33620, USA. Electronic address: uwe.rix@moffitt.org.
Cell Chem Biol ; 31(2): 284-297.e10, 2024 Feb 15.
Article em En | MEDLINE | ID: mdl-37848034
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Proteínas Tirosina Quinases / Carcinoma Pulmonar de Células não Pequenas / Lactamas / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: Cell Chem Biol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Proteínas Tirosina Quinases / Carcinoma Pulmonar de Células não Pequenas / Lactamas / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: Cell Chem Biol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos