Design, synthesis, and biological investigation of selective human carbonic anhydrase II, IX, and XII inhibitors using 7-aryl/heteroaryl triazolopyrimidines bearing a sulfanilamide scaffold.

Romagnoli, Romeo; De Ventura, Tiziano; Manfredini, Stefano; Baldini, Erika; Supuran, Claudiu T; Nocentini, Alessio; Brancale, Andrea; Bortolozzi, Roberta; Manfreda, Lorenzo; Viola, Giampietro

Romagnoli, Romeo; De Ventura, Tiziano; Manfredini, Stefano; Baldini, Erika; Supuran, Claudiu T; Nocentini, Alessio; Brancale, Andrea; Bortolozzi, Roberta; Manfreda, Lorenzo; Viola, Giampietro.

Afiliação

Romagnoli R; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.
De Ventura T; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.
Manfredini S; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
Baldini E; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy.
Nocentini A; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy.
Brancale A; Vysoká Skola Chemicko-Technologická v Praze, Prague, Czech Republic.
Bortolozzi R; Department of Woman's and Child's Health, Hemato-Oncology Lab, University of Padova, Padova, Italy.
Manfreda L; Department of Pharmaceutical and Pharmacological Sciences, Section of Pharmacology, University of Padova, Padova, Italy.
Viola G; Laboratory of Experimental Pharmacology, Istituto di Ricerca Pediatrica (IRP), Padova, Italy.

J Enzyme Inhib Med Chem ; 38(1): 2270180, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37850364

Assuntos

Antígenos de Neoplasias; Anidrase Carbônica II; Humanos; Anidrase Carbônica II/metabolismo; Relação Estrutura-Atividade; Anidrase Carbônica IX/metabolismo; Anidrase Carbônica I/metabolismo; Isoformas de Proteínas; Sulfanilamidas; Inibidores da Anidrase Carbônica/farmacologia; Estrutura Molecular

Palavras-chave

Carbonic anhydrase inhibitors; [1,2,4]triazolo[15-a]pyrimidine; antiproliferative activity; structureactivity relationship; sulphanilamide

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anidrase Carbônica II / Antígenos de Neoplasias Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália

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