Preliminary results in tracheal replacement using stented aortic matrices for primary extensive tracheal cancer.
JTCVS Tech
; 21: 227-236, 2023 Oct.
Article
em En
| MEDLINE
| ID: mdl-37854807
ABSTRACT
Objective:
Recent studies have demonstrated the feasibility and favorable long-term results of tracheobronchial replacement using stented cryopreserved aortic allografts. We propose to investigate the outcomes of this emerging technique in the subgroup of patients with extensive tracheal cancer.Methods:
This study was based on 13 patients with primary extensive tracheal cancer extracted from the prospective registry TRITON-01 (ClinicalTrials.gov Identifier NCT04263129), which included 40 patients in total. We analyzed early and late outcomes in this subset of patients.Results:
From March 2019 to September 2022, 13 patients were included in the study. There were 9 female and 4 male patients, with a mean age of 53.9 years [36-71 years]. They had tracheal replacement for extended adenoid cystic carcinoma (n = 11), squamous cell carcinoma (n = 1), and mucoepidermoid carcinoma (n = 1). A venovenous extracorporeal membrane oxygenation was used in the 6 last cases. The mean length of resection was 81 mm [50-120 mm]. There was no 30-day postoperative mortality. A complete resection (R0) was achieved in 11 patients. The main late complications consisted of tracheal granulomas related to the stent and requiring repeated bronchoscopies (n = 9), pneumonia (n = 3), airway infection (n = 1), bronchoesophageal fistula (n = 1), mechanical stent obstruction requiring change (n = 2), and mediastinitis treated by antibiotics, drainage, and omentoplasty (n = 1). With a maximal follow-up of 3 years and 7 months, cancer recurrence was observed in 2 patients. All patients were alive at last follow-up except 2 (84.6%).Conclusions:
Airway replacement using stented CAA represents a feasible and promising solution for extensive tracheal cancer.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
JTCVS Tech
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
França