Umbilical cord blood hematological parameters in predicting early onset neonatal sepsis (EOS) - a prospective cohort study.
J Perinat Med
; 52(1): 102-107, 2024 Jan 29.
Article
em En
| MEDLINE
| ID: mdl-37856248
ABSTRACT
OBJECTIVES:
In low and middle income countries, there is a need for affordable and accurate biomarkers to identify neonates at risk of early onset neonatal sepsis (EOS). Cord blood hematological parameters if reliable and accurate for the detection of EOS are cost effective and can reduce the need for repeated venipuncture in the neonate.METHODS:
In this prospective cohort study, the umbilical cord parameters of newborns with gestational age >34 weeks were collected. These neonates were followed up for 72â¯h and septic screen was employed in those babies who had risk factors or developed clinical features of sepsis. The cord blood parameters of the normal newborn and those who had sepsis were analyzed.RESULTS:
A total of 513 neonates were enrolled for the study, 32 required septic screening of whom 13 neonates were found to meet the criteria for sepsis either blood culture positive or sepsis screen positive with clinical features. Cord blood parameters were analyzed using independent t test. Red cell distribution width (RDW) and band cells were statistically significant (p 0.007 and 0.009 respectively) between the septic and normal neonates. Increased RDW had a sensitivity of 61.54â¯%, specificity of 54.60â¯%. Increased band cells with a cut off of >15 cells had a sensitivity of 7.7â¯% with specificity of 100â¯% with higher numbers in septic neonates. Increased RDW and band cells in combination had sensitivity of 61.54â¯% and specificity of 54.6â¯%.CONCLUSIONS:
RDW and band cell can be potential markers of EOS in cord blood but require further study in a larger population.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sepse
/
Sepse Neonatal
Limite:
Humans
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Infant
/
Newborn
Idioma:
En
Revista:
J Perinat Med
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Índia