Photobac derived from bacteriochlorophyll-a shows potential for treating brain tumor in animal models by photodynamic therapy with desired pharmacokinetics and limited toxicity in rats and dogs.

Durrani, Farukh A; Cacaccio, Joseph; Turowski, Steven G; Dukh, Mykhaylo; Bshara, Wiam; Curtin, Leslie; Sexton, Sandra; Spernyak, Joseph A; Pandey, Ravindra K

Durrani, Farukh A; Cacaccio, Joseph; Turowski, Steven G; Dukh, Mykhaylo; Bshara, Wiam; Curtin, Leslie; Sexton, Sandra; Spernyak, Joseph A; Pandey, Ravindra K.

Afiliação

Durrani FA; PDT Center, Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA; Photolitec, LLC, 73 High Street, Buffalo, NY 14223, USA.
Cacaccio J; PDT Center, Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA; Photolitec, LLC, 73 High Street, Buffalo, NY 14223, USA.
Turowski SG; Translational Imaging Shared Resources, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Dukh M; PDT Center, Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA; Photolitec, LLC, 73 High Street, Buffalo, NY 14223, USA.
Bshara W; Department of Pathology, Pathology Network Shared Resources, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Curtin L; Comparative Oncology Shared Resources, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Sexton S; Comparative Oncology Shared Resources, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Spernyak JA; Translational Imaging Shared Resources, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Pandey RK; PDT Center, Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA. Electronic address: Ravindra.pandey@roswellpark.org.

Biomed Pharmacother ; 168: 115731, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37857248

Assuntos

Neoplasias Encefálicas; Glioblastoma; Fotoquimioterapia; Ratos; Cães; Animais; Camundongos; Humanos; Suínos; Bacterioclorofilas/uso terapêutico; Glioblastoma/patologia; Fotoquimioterapia/métodos; Bacterioclorofila A/uso terapêutico; Porco Miniatura; Neoplasias Encefálicas/tratamento farmacológico; Neoplasias Encefálicas/patologia; Fármacos Fotossensibilizantes/farmacologia; Fármacos Fotossensibilizantes/uso terapêutico; Modelos Animais

Palavras-chave

AUC: Area under the curve; Cmax: Maximum concentration; Glioblastoma; Pharmacokinetic and Toxicokinetic; Pharmacology; Photodynamic Therapy; Photosensitizer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Neoplasias Encefálicas / Glioblastoma Limite: Animals / Humans Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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