A new chink in cancer's armor: Unleashing cell death by selective PP5 inhibition.
Cell Chem Biol
; 30(10): 1186-1188, 2023 10 19.
Article
em En
| MEDLINE
| ID: mdl-37863031
ABSTRACT
Serine/threonine protein phosphatases play a significant role in the survival and propagation of multiple cancers. In this issue of Cell Chemical Biology, Ahanin et al.1 demonstrate that protein phosphatase 5 (PP5) dephosphorylates and inactivates the cell death effector protein FADD independently of Hsp90, and they identify a selective PP5 inhibitor as a new therapeutic strategy for renal cancer.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas Fosfatases
/
Neoplasias
Idioma:
En
Revista:
Cell Chem Biol
Ano de publicação:
2023
Tipo de documento:
Article