Hypoxic Preconditional Engineering Small Extracellular Vesicles Promoted Intervertebral Disc Regeneration by Activating Mir-7-5p/NF-&#922;b/Cxcl2 Axis.

Hu, Hongxing; Wang, Zhaojie; Yang, Huiyi; Bai, Yuxin; Zhu, Rongrong; Cheng, Liming

Hypoxic Preconditional Engineering Small Extracellular Vesicles Promoted Intervertebral Disc Regeneration by Activating Mir-7-5p/NF-Κb/Cxcl2 Axis.

Hu, Hongxing; Wang, Zhaojie; Yang, Huiyi; Bai, Yuxin; Zhu, Rongrong; Cheng, Liming.

Afiliação

Hu H; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Department of Orthopedics, Tongji Hospital Affiliated to Tongji University, School of Medicine, Tongji University, Shanghai, 200092, China.
Wang Z; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Department of Orthopedics, Tongji Hospital Affiliated to Tongji University, School of Medicine, Tongji University, Shanghai, 200092, China.
Yang H; Frontier Science Center for Stem Cell Research, School of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Bai Y; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Department of Orthopedics, Tongji Hospital Affiliated to Tongji University, School of Medicine, Tongji University, Shanghai, 200092, China.
Zhu R; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Department of Orthopedics, Tongji Hospital Affiliated to Tongji University, School of Medicine, Tongji University, Shanghai, 200092, China.
Cheng L; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Department of Orthopedics, Tongji Hospital Affiliated to Tongji University, School of Medicine, Tongji University, Shanghai, 200092, China.

Adv Sci (Weinh) ; 10(35): e2304722, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37870186

Assuntos

Vesículas Extracelulares; Degeneração do Disco Intervertebral; Disco Intervertebral; MicroRNAs; Humanos; Vesículas Extracelulares/metabolismo; Disco Intervertebral/metabolismo; Degeneração do Disco Intervertebral/terapia; Degeneração do Disco Intervertebral/metabolismo; MicroRNAs/genética; MicroRNAs/metabolismo; NF-kappa B/metabolismo; NF-kappa B/farmacologia; NF-kappa B/uso terapêutico; Regeneração; Quimiocina CXCL2/metabolismo

Palavras-chave

hypoxic preconditioning; intervertebral disc degradation; miRNA; small extracellular vesicles

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Degeneração do Disco Intervertebral / Vesículas Extracelulares / Disco Intervertebral Limite: Humans Idioma: En Revista: Adv Sci (Weinh) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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