SGLT2 and DPP4 inhibitors improve Alzheimer's disease-like pathology and cognitive function through distinct mechanisms in a T2D-AD mouse model.

Sim, A Young; Choi, Da Hyun; Kim, Jong Youl; Kim, Eun Ran; Goh, A-Ra; Lee, Yong-Ho; Lee, Jong Eun

Sim, A Young; Choi, Da Hyun; Kim, Jong Youl; Kim, Eun Ran; Goh, A-Ra; Lee, Yong-Ho; Lee, Jong Eun.

Afiliação

Sim AY; Department of Anatomy, Yonsei University College of Medicine, Seoul, Republic of Korea; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: ayoung2kr@gmail.com.
Choi DH; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Systems Biology, Glycosylation Network Research Center, Yonsei University, Seoul, Republic of Korea; Interdisciplinary Program of Integrated OMICS for Biomedical Science, Yonsei University
Kim JY; Department of Anatomy, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: jongyoul74@gmail.com.
Kim ER; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Goh AR; Department of Anatomy, Yonsei University College of Medicine, Seoul, Republic of Korea; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: karara7676@gmail.com.
Lee YH; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Systems Biology, Glycosylation Network Research Center, Yonsei University, Seoul, Republic of Korea; Interdisciplinary Program of Integrated OMICS for Biomedical Science, Yonsei University
Lee JE; Department of Anatomy, Yonsei University College of Medicine, Seoul, Republic of Korea; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea; Brain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Kor

Biomed Pharmacother ; 168: 115755, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37871560

Assuntos

Doença de Alzheimer; Diabetes Mellitus Tipo 2; Inibidores da Dipeptidil Peptidase IV; Resistência à Insulina; Inibidores do Transportador 2 de Sódio-Glicose; Camundongos; Animais; Diabetes Mellitus Tipo 2/metabolismo; Doença de Alzheimer/metabolismo; Inibidores da Dipeptidil Peptidase IV/farmacologia; Inibidores da Dipeptidil Peptidase IV/uso terapêutico; Resistência à Insulina/fisiologia; Peptídeos beta-Amiloides/metabolismo; Inibidores do Transportador 2 de Sódio-Glicose/farmacologia; Inibidores do Transportador 2 de Sódio-Glicose/uso terapêutico; Transportador 2 de Glucose-Sódio; Dipeptidil Peptidase 4/metabolismo; Hipoglicemiantes/farmacologia; Hipoglicemiantes/uso terapêutico; Insulina/metabolismo; Cognição; Modelos Animais de Doenças; Peso Corporal

Palavras-chave

Alzheimer's disease; Amyloid ß; Dipeptidyl peptidase-4 inhibitor; Hyperphosphorylated tau; Sodiumglucose cotransporter-2 inhibitor; Type 2 diabetes mellitus

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Diabetes Mellitus Tipo 2 / Inibidores da Dipeptidil Peptidase IV / Doença de Alzheimer / Inibidores do Transportador 2 de Sódio-Glicose Limite: Animals Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2023 Tipo de documento: Article

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