Association between light rare earth elements in maternal plasma and the risk of spontaneous preterm birth: a nested case-control study from the Beijing birth cohort study.
Environ Health
; 22(1): 73, 2023 10 23.
Article
em En
| MEDLINE
| ID: mdl-37872585
ABSTRACT
BACKGROUND:
Parental exposure to rare earth elements (REEs) could increase the risk of premature rupture of membranes, a major cause of spontaneous preterm birth (SPB). In addition, different subtypes of SPB, such as spontaneous preterm labor (SPL) and preterm premature rupture of membranes (PPROM), may have different susceptibility to environmental exposure. Therefore, we investigated the potential associations between REE exposure in different trimesters and SPB and its subtypes.METHODS:
A nested case-control study was performed. We included 244 women with SPB as cases and 244 women with full-term delivery as controls. The plasma concentrations of light REEs were measured in the first and third trimesters. Logistic regression was used to analyze the associations between single REE levels and SPB, and Bayesian kernel machine regression (BKMR) was used to analyze the mixed-exposure effect.RESULTS:
Exposure to light REEs was associated with SPB and its subtypes only in the third trimester. Specifically, the intermediate- and highest-tertile concentration groups of La and the highest-tertile concentration group of Sm were associated with an increased risk of SPL, with adjusted odds ratios (AORs) of 2.00 (95% CIs 1.07-3.75), 1.87 (95% CIs 1.01-3.44), and 1.82 (95% CIs 1.00-3.30), respectively. The highest-tertile concentration group of Pr was associated with an increased risk of PPROM, with an AOR of 1.69 (95% CIs 1.00-2.85). Similar results were also found in BKMR models.CONCLUSIONS:
La and Sm levels in plasma may be associated with the risk of SPL, and Pr levels in plasma may be associated with the risk of PPROM.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nascimento Prematuro
Limite:
Female
/
Humans
/
Newborn
País/Região como assunto:
Asia
Idioma:
En
Revista:
Environ Health
Assunto da revista:
SAUDE AMBIENTAL
Ano de publicação:
2023
Tipo de documento:
Article