Physiological Temperature and Osmotic Changes Drive Dynamic Proteome Alterations in the Leptospiral Outer Membrane and Enhance Protein Export Systems.

Phukan, Homen; Sarma, Abhijit; Rex, Devasahayam Arokia Balaya; Christie, Swamidurai Arul Diana; Sabu, Sarath Kizhakkemuriyil; Hariharan, Suneetha; Prasad, Thottethodi Subrahmanya Keshava; Madanan, Madathiparambil Gopalakrishnan

Phukan, Homen; Sarma, Abhijit; Rex, Devasahayam Arokia Balaya; Christie, Swamidurai Arul Diana; Sabu, Sarath Kizhakkemuriyil; Hariharan, Suneetha; Prasad, Thottethodi Subrahmanya Keshava; Madanan, Madathiparambil Gopalakrishnan.

Afiliação

Phukan H; Department of Biochemistry, ICMR - Regional Medical Research Centre, Port Blair 744103, Andaman and Nicobar Islands, India.
Sarma A; Department of Biochemistry, ICMR - Regional Medical Research Centre, Port Blair 744103, Andaman and Nicobar Islands, India.
Rex DAB; Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore 575018, India.
Christie SAD; Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.
Sabu SK; Department of Biochemistry, ICMR - Regional Medical Research Centre, Port Blair 744103, Andaman and Nicobar Islands, India.
Hariharan S; Department of Biochemistry, ICMR - Regional Medical Research Centre, Port Blair 744103, Andaman and Nicobar Islands, India.
Prasad TSK; Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore 575018, India.
Madanan MG; Department of Biochemistry, ICMR - Regional Medical Research Centre, Port Blair 744103, Andaman and Nicobar Islands, India.

J Proteome Res ; 22(11): 3447-3463, 2023 11 03.

Article em En | MEDLINE | ID: mdl-37877620

Assuntos

Leptospira; Leptospirose; Vacinas; Humanos; Proteoma/genética; Proteoma/metabolismo; Proteínas da Membrana Bacteriana Externa/metabolismo; Temperatura; Cromatografia Líquida; Espectrometria de Massas em Tandem; Leptospira/metabolismo

Palavras-chave

differential expression; leptospirosis; mass spectrometry; outer membrane protein; proteomics; zoonotic disease

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas / Leptospira / Leptospirose Limite: Humans Idioma: En Revista: J Proteome Res Assunto da revista: BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Índia

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