RNA N6-methyladenosine demethylase FTO inhibits glucocorticoid-induced osteoblast differentiation and function in bone marrow mesenchymal stem cells.

Feng, Lingling; Zhao, Wei; Fan, Yunshan; Yuan, Chengcheng; Zhang, Xiaohua

Feng, Lingling; Zhao, Wei; Fan, Yunshan; Yuan, Chengcheng; Zhang, Xiaohua.

Afiliação

Feng L; Department of Paediatrics, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China.
Zhao W; Department of Orthopedic Surgery, Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, China.
Fan Y; Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Yuan C; Department of Paediatrics, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China.
Zhang X; Department of Paediatrics, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China.

J Cell Biochem ; 124(11): 1835-1847, 2023 11.

Article em En | MEDLINE | ID: mdl-37882437

Assuntos

Glucocorticoides; Células-Tronco Mesenquimais; Glucocorticoides/farmacologia; Osteogênese/genética; RNA/metabolismo; Diferenciação Celular; Adenosina/farmacologia; Adenosina/metabolismo; Células-Tronco Mesenquimais/metabolismo; Osteoblastos/metabolismo

Palavras-chave

FTO; N6-methyladenosine; dexamethasone; mRNA stability; osteoblast differentiation; proliferation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Mesenquimais / Glucocorticoides Idioma: En Revista: J Cell Biochem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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