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The molecular basis of drug selectivity for α5 subunit-containing GABAA receptors.
Kasaragod, Vikram Babu; Malinauskas, Tomas; Wahid, Ayla A; Lengyel, Judith; Knoflach, Frederic; Hardwick, Steven W; Jones, Charlotte F; Chen, Wan-Na; Lucas, Xavier; El Omari, Kamel; Chirgadze, Dimitri Y; Aricescu, A Radu; Cecere, Giuseppe; Hernandez, Maria-Clemencia; Miller, Paul S.
Afiliação
  • Kasaragod VB; Department of Pharmacology, University of Cambridge, Cambridge, UK.
  • Malinauskas T; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
  • Wahid AA; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Lengyel J; Department of Pharmacology, University of Cambridge, Cambridge, UK.
  • Knoflach F; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland.
  • Hardwick SW; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland.
  • Jones CF; CryoEM Facility, Department of Biochemistry, University of Cambridge, Cambridge, UK.
  • Chen WN; Department of Pharmacology, University of Cambridge, Cambridge, UK.
  • Lucas X; Department of Pharmacology, University of Cambridge, Cambridge, UK.
  • El Omari K; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center, Basel, Switzerland.
  • Chirgadze DY; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK.
  • Aricescu AR; CryoEM Facility, Department of Biochemistry, University of Cambridge, Cambridge, UK.
  • Cecere G; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
  • Hernandez MC; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center, Basel, Switzerland.
  • Miller PS; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland. maria-clemencia.hernandez@roche.com.
Nat Struct Mol Biol ; 30(12): 1936-1946, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37903907
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de GABA-A / Ácido gama-Aminobutírico Idioma: En Revista: Nat Struct Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de GABA-A / Ácido gama-Aminobutírico Idioma: En Revista: Nat Struct Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido