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Amyloid-beta and tau protein beyond Alzheimer's disease.
Abyadeh, Morteza; Gupta, Vivek; Paulo, Joao A; Mahmoudabad, Arezoo Gohari; Shadfar, Sina; Mirshahvaladi, Shahab; Gupta, Veer; Nguyen, Christine T O; Finkelstein, David I; You, Yuyi; Haynes, Paul A; Salekdeh, Ghasem H; Graham, Stuart L; Mirzaei, Mehdi.
Afiliação
  • Abyadeh M; ProGene Technologies Pty Ltd., Sydney, NSW, Australia.
  • Gupta V; Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University, Macquarie Park, North Ryde, Sydney, NSW, Australia.
  • Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
  • Mahmoudabad AG; ProGene Technologies Pty Ltd., Sydney, NSW, Australia.
  • Shadfar S; Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University, Macquarie Park, North Ryde, Sydney, NSW, Australia.
  • Mirshahvaladi S; Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University, Macquarie Park, North Ryde, Sydney, NSW, Australia.
  • Gupta V; School of Medicine, Deakin University, Geelong, VIC, Australia.
  • Nguyen CTO; Department of Optometry and Vision Sciences, School of Health Sciences, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne, Parkville, VIC, Australia.
  • Finkelstein DI; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
  • You Y; Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University, Macquarie Park, North Ryde, Sydney, NSW, Australia.
  • Haynes PA; School of Natural Sciences, Macquarie University, Macquarie Park, NSW, Australia.
  • Salekdeh GH; School of Natural Sciences, Macquarie University, Macquarie Park, NSW, Australia.
  • Graham SL; Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University, Macquarie Park, North Ryde, Sydney, NSW, Australia.
  • Mirzaei M; Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University, Macquarie Park, North Ryde, Sydney, NSW, Australia.
Neural Regen Res ; 19(6): 1262-1276, 2024 Jun 01.
Article em En | MEDLINE | ID: mdl-37905874
ABSTRACT
ABSTRACT The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. Physiologically, these two proteins are produced and expressed within the normal human body. However, under pathological conditions, abnormal expression, post-translational modifications, conformational changes, and truncation can make these proteins prone to aggregation, triggering specific disease-related cascades. Recent studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, as well as retinal neurodegenerative diseases like Glaucoma and age-related macular degeneration. Additionally, these proteins have been linked to cardiovascular disease, cancer, traumatic brain injury, and diabetes, which are all leading causes of morbidity and mortality. In this comprehensive review, we provide an overview of the connections between amyloid-beta and tau proteins and a spectrum of disorders.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Neural Regen Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Neural Regen Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália