Direct arene trifluoromethylation enabled by promiscuous activity of fungal laccase.
Org Biomol Chem
; 21(45): 8975-8978, 2023 11 22.
Article
em En
| MEDLINE
| ID: mdl-37933470
ABSTRACT
Laccase from Trametes versicolor was found to oxidize non-phenolic arenes and enable the trifluoromethylation of arenes in the presence of in situ generated CF3 radicals at a catalyst loading as low as 0.0034%. The biocatalytic trifluoromethylation proceeded under mild conditions and could increase the yield by up to 12 fold, compared to the control.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lacase
/
Trametes
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2023
Tipo de documento:
Article