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A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.
Sri, Sarmi; Greenstein, Adam; Granata, Alessandra; Collcutt, Alex; Jochems, Angela C C; McColl, Barry W; Castro, Blanca Díaz; Webber, Caleb; Reyes, Carmen Arteaga; Hall, Catherine; Lawrence, Catherine B; Hawkes, Cheryl; Pegasiou-Davies, Chrysia-Maria; Gibson, Claire; Crawford, Colin L; Smith, Colin; Vivien, Denis; McLean, Fiona H; Wiseman, Frances; Brezzo, Gaia; Lalli, Giovanna; Pritchard, Harry A T; Markus, Hugh S; Bravo-Ferrer, Isabel; Taylor, Jade; Leiper, James; Berwick, Jason; Gan, Jian; Gallacher, John; Moss, Jonathan; Goense, Jozien; McMullan, Letitia; Work, Lorraine; Evans, Lowri; Stringer, Michael S; Ashford, Mlj; Abulfadl, Mohamed; Conlon, Nina; Malhotra, Paresh; Bath, Philip; Canter, Rebecca; Brown, Rosalind; Ince, Selvi; Anderle, Silvia; Young, Simon; Quick, Sophie; Szymkowiak, Stefan; Hill, Steve; Allan, Stuart; Wang, Tao.
Afiliação
  • Sri S; UK Dementia Research Institute Headquarters, 6th Floor Maple House, London W1T 7NF, UK.
  • Greenstein A; Division of Cardiovascular Sciences, The University of Manchester, Manchester M13 9PL, UK.
  • Granata A; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
  • Collcutt A; Department of Clinical Neurosciences, Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge CB2 0BB, UK.
  • Jochems ACC; UK Dementia Research Institute Headquarters, 6th Floor Maple House, London W1T 7NF, UK.
  • McColl BW; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Castro BD; UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
  • Webber C; UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
  • Reyes CA; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.
  • Hall C; UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
  • Lawrence CB; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.
  • Hawkes C; UK Dementia Research Institute Cardiff, Cardiff University, Cardiff CF24 4HQ, UK.
  • Pegasiou-Davies CM; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Gibson C; UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
  • Crawford CL; School of Psychology and Sussex Neuroscience, University of Sussex, Falmer, Brighton, East Sussex, UK.
  • Smith C; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
  • Vivien D; Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • McLean FH; Biomedical and Life Sciences, Lancaster University, Lancaster, UK.
  • Wiseman F; UK Dementia Research Institute Headquarters, 6th Floor Maple House, London W1T 7NF, UK.
  • Brezzo G; School of Psychology, University of Nottingham, Nottingham NG7 2UH, UK.
  • Lalli G; UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
  • Pritchard HAT; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.
  • Markus HS; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Bravo-Ferrer I; Physiopathology and Imaging of Neurological Disorders (PhIND), Normandie University, UNICAEN, INSERM UMR-S U1237, , GIP Cyceron, Institute Blood and Brain @ Caen-Normandie (BB@C), Caen, France.
  • Taylor J; Department of clinical research, Caen-Normandie University Hospital, Caen, France.
  • Leiper J; Division of Systems Medicine, School of Medicine, Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UK.
  • Berwick J; UK Dementia Research Institute, University College London, London WC1N 3BG, UK.
  • Gan J; UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
  • Gallacher J; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.
  • Moss J; UK Dementia Research Institute Headquarters, 6th Floor Maple House, London W1T 7NF, UK.
  • Goense J; Division of Cardiovascular Sciences, The University of Manchester, Manchester M13 9PL, UK.
  • McMullan L; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
  • Work L; Stroke Research Group, Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.
  • Evans L; UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
  • Stringer MS; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.
  • Ashford M; Division of Cardiovascular Sciences, The University of Manchester, Manchester M13 9PL, UK.
  • Abulfadl M; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
  • Conlon N; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
  • Malhotra P; Department of Psychology, University of Sheffield, Sheffield, UK.
  • Bath P; Neuroscience Institute, University of Sheffield, Sheffield, UK.
  • Canter R; Healthy Lifespan Institute, University of Sheffield, Sheffield, UK.
  • Brown R; UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
  • Ince S; Centre for Discovery Brain Sciences, Chancellor's Building, The University of Edinburgh, Edinburgh, UK.
  • Anderle S; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
  • Young S; UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK.
  • Quick S; Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK.
  • Szymkowiak S; The Roslin Institute, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, UK.
  • Hill S; Neuroscience Program, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
  • Allan S; Department of Psychology, University of Illinois, Urbana-Champaign, Champaign, IL, USA.
  • Wang T; Department of Bioengineering, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
Cereb Circ Cogn Behav ; 5: 100189, 2023.
Article em En | MEDLINE | ID: mdl-37941765
ABSTRACT
Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Cereb Circ Cogn Behav Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Cereb Circ Cogn Behav Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido