The topography of cell loss from locus caeruleus in Alzheimer's disease.
J Neurol Sci
; 76(2-3): 335-45, 1986 Dec.
Article
em En
| MEDLINE
| ID: mdl-3794754
ABSTRACT
A topographical analysis of nerve cell loss from locus caeruleus in Alzheimer's disease has shown that cell loss is confined to the dorsal areas and occurs uniformly throughout the rostrocaudal length of the locus. By contrast there is no significant cell loss from ventral parts of the locus, at any point along its rostrocaudal length. Dorsally located neurones of the locus project to cerebral cortex; ventrally located neurones to non-cortical areas such as basal ganglia, cerebellum and spinal cord. These data suggest that damage to nerve cells of locus caeruleus in Alzheimer's disease relates primarily to pathological events within their terminal fields, with perikaryal loss following as a secondary retrograde change. The senile plaque may represent the actual site of the damage to nerve terminals.
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Base de dados:
MEDLINE
Assunto principal:
Locus Cerúleo
/
Doença de Alzheimer
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Neurol Sci
Ano de publicação:
1986
Tipo de documento:
Article