Target discovery of bioactive natural products with native-compound-coupled CNBr-activated Sepharose 4B beads (NCCB): Applications, mechanisms and outlooks.

Zhang, Yueteng; Zhang, Junjie; Li, Menglong; Qiao, Yan; Wang, Wei; Ma, Lu; Liu, Kangdong

Zhang, Yueteng; Zhang, Junjie; Li, Menglong; Qiao, Yan; Wang, Wei; Ma, Lu; Liu, Kangdong.

Afiliação

Zhang Y; Basic Medical Research Center, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Zhang J; Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Li M; Basic Medical Research Center, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Qiao Y; Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Wang W; Departments of Pharmacology & Toxicology and Chemistry & Biochemistry, and BIO5 Institute, University of Arizona, Tucson, AZ 85721, United States.
Ma L; Basic Medical Research Center, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China. Electronic address: luma@zzu.edu.
Liu K; Basic Medical Research Center, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China; Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China. Electronic address: kdliu@zzu.edu.cn.

Bioorg Med Chem ; 96: 117483, 2023 12 15.

Article em En | MEDLINE | ID: mdl-37951136

Assuntos

Produtos Biológicos; Sefarose; Produtos Biológicos/farmacologia; Descoberta de Drogas

Palavras-chave

CNBr-activated Sepharose 4B beads; Chemical proteomics; Mechanism of action; Natural products; Target discovery

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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