A Composite Morphometric Duodenal Biopsy Mucosal Scale for Celiac Disease Encompassing Both Morphology and Inflammation.
Clin Gastroenterol Hepatol
; 2023 Nov 11.
Article
em En
| MEDLINE
| ID: mdl-37952751
ABSTRACT
BACKGROUND & AIMS:
Villus height to crypt depth ratio (VhCd) and intraepithelial lymphocytes (IEL) are key measures of histology of the small intestine in celiac disease. Although the field of celiac disease has advanced, there remains no broadly accepted measure of mucosal injury. We assessed whether a composite VhCd and IEL scale (VCIEL) can improve accuracy and statistical precision for assessing histology, compared with individual measures.METHODS:
The formulation of the VCIEL composite histologic scale was based on combining the VhCd and IEL measurements for individual patients with equal weighting, by converting each scale to a fraction of their standard deviation and summing the results. The VCIEL formula was applied to several clinical trials and the results for VhCd and IEL were compared with those for VCIEL with regards to clinical significance (effect size) and statistical significance.RESULTS:
For the ALV003-1021 trial, we observed an effect size and P value (analysis of covariance) of 1.37 and 0.038 for ΔVhCd, 1.17 and 0.005 for ΔIEL, and 1.86 and 0.004 for ΔVCIEL. For the similar gluten-challenge IMGX003-NCCIH-1721 trial, the corresponding results were 0.76 and 0.057 for ΔVhCd, 0.98 and 0.018 for ΔIEL, and 1.14 and 0.007 for ΔVCIEL. Similar improvements with the use of VCIEL over individual VhCd and IEL measures were observed for other studies, including a nontherapeutic gluten challenge study.CONCLUSIONS:
The composite VCIEL scale combining VhCd and IEL values seems to improve accuracy and statistical precision compared with either component alone.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Clin Gastroenterol Hepatol
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2023
Tipo de documento:
Article