Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules.
Molecules
; 28(21)2023 Oct 30.
Article
em En
| MEDLINE
| ID: mdl-37959771
ABSTRACT
Selenium is an essential trace element in living organisms, and is present in selenoenzymes with antioxidant activity, like glutathione peroxidase (GPx) and thioredoxin reductase (TrxR). The search for small selenium-containing molecules that mimic selenoenzymes is a strong field of research in organic and medicinal chemistry. In this review, we review the synthesis and bioassays of new and known organoselenium compounds with antioxidant activity, covering the last five years. A detailed description of the synthetic procedures and the performed in vitro and in vivo bioassays is presented, highlighting the most active compounds in each series.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Selênio
/
Oligoelementos
/
Compostos Organosselênicos
Idioma:
En
Revista:
Molecules
Assunto da revista:
BIOLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Brasil