DNMT3a-mediated methylation of PPARÎ³ promote intervertebral disc degeneration by regulating the NF-&#954;B pathway.

Cheng, Peng; Wei, Hang-Zhi; Chen, Hai-Wei; Wang, Zhi-Qiang; Mao, Peng; Zhang, Hai-Hong

DNMT3a-mediated methylation of PPARÎ³ promote intervertebral disc degeneration by regulating the NF-κB pathway.

Cheng, Peng; Wei, Hang-Zhi; Chen, Hai-Wei; Wang, Zhi-Qiang; Mao, Peng; Zhang, Hai-Hong.

Afiliação

Cheng P; Department of Emergency Medicine, Lanzhou University Second Hospital, Lanzhou, Gansu, PR China.
Wei HZ; Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu Province, PR China.
Chen HW; Department of Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, PR China.
Wang ZQ; Department of Emergency Medicine, Lanzhou University Second Hospital, Lanzhou, Gansu, PR China.
Mao P; Department of Emergency Medicine, Lanzhou University Second Hospital, Lanzhou, Gansu, PR China.
Zhang HH; The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, PR China.

J Cell Mol Med ; 28(2): e18048, 2024 Jan.

Article em En | MEDLINE | ID: mdl-37986543

Assuntos

Degeneração do Disco Intervertebral; Disco Intervertebral; Núcleo Pulposo; Animais; Humanos; Ratos; DNA Metiltransferase 3A; Epigênese Genética; Disco Intervertebral/patologia; Degeneração do Disco Intervertebral/patologia; Metilação; NF-kappa B/metabolismo; Núcleo Pulposo/patologia; PPAR gama/genética; PPAR gama/metabolismo; Ratos Sprague-Dawley; Transdução de Sinais

Palavras-chave

DNMT3a; PPARÎ³; intervertebral disc degeneration; low back pain

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Degeneração do Disco Intervertebral / Núcleo Pulposo / Disco Intervertebral Limite: Animals / Humans Idioma: En Revista: J Cell Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2024 Tipo de documento: Article

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