Apoptotic signaling: Beyond cell death.
Semin Cell Dev Biol
; 156: 22-34, 2024 03 15.
Article
em En
| MEDLINE
| ID: mdl-37988794
ABSTRACT
Apoptosis is the best described form of regulated cell death, and was, until relatively recently, considered irreversible once particular biochemical points-of-no-return were activated. In this manuscript, we examine the mechanisms cells use to escape from a self-amplifying death signaling module. We discuss the role of feedback, dynamics, propagation, and noise in apoptotic signaling. We conclude with a revised model for the role of apoptosis in animal development, homeostasis, and disease.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Apoptose
Limite:
Animals
Idioma:
En
Revista:
Semin Cell Dev Biol
Assunto da revista:
EMBRIOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article