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Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist.
Litvinchuk, Alexandra; Suh, Jung H; Guo, Jing L; Lin, Karin; Davis, Sonnet S; Bien-Ly, Nga; Tycksen, Eric; Tabor, G Travis; Remolina Serrano, Javier; Manis, Melissa; Bao, Xin; Lee, Choonghee; Bosch, Megan; Perez, Enmanuel J; Yuede, Carla M; Cashikar, Anil G; Ulrich, Jason D; Di Paolo, Gilbert; Holtzman, David M.
Afiliação
  • Litvinchuk A; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • Suh JH; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.
  • Guo JL; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.
  • Lin K; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.
  • Davis SS; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.
  • Bien-Ly N; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.
  • Tycksen E; Genome Technology Access Center, McDonnell Genome Institute, St. Louis, MO 63110, USA.
  • Tabor GT; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • Remolina Serrano J; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • Manis M; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • Bao X; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • Lee C; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • Bosch M; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • Perez EJ; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • Yuede CM; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • Cashikar AG; Department of Psychiatry, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • Ulrich JD; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA.
  • Di Paolo G; Denali Therapeutics Inc., South San Francisco, CA 94080, USA. Electronic address: dipaolo@dnli.com.
  • Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63108, USA. Electronic address: holtzman@wustl.edu.
Neuron ; 112(3): 384-403.e8, 2024 Feb 07.
Article em En | MEDLINE | ID: mdl-37995685
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tauopatias / Doença de Alzheimer Limite: Animals Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tauopatias / Doença de Alzheimer Limite: Animals Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos