Differential Impact of Smoking on Methylome and Transcriptome in Crohn's Disease and Ulcerative Colitis.

Yan Ang, Qi; Plichta, Damian; Kim, Sean; Hyun-A Kim, Iris; Gregory, Sadie; Xia, Yan; Lau, Helena; Xavier, Ramnik; Ananthakrishnan, Ashwin N

Yan Ang, Qi; Plichta, Damian; Kim, Sean; Hyun-A Kim, Iris; Gregory, Sadie; Xia, Yan; Lau, Helena; Xavier, Ramnik; Ananthakrishnan, Ashwin N.

Afiliação

Yan Ang Q; Broad Institute, Cambridge, MA, USA.
Plichta D; Broad Institute, Cambridge, MA, USA.
Kim S; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.
Hyun-A Kim I; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.
Gregory S; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.
Xia Y; Broad Institute, Cambridge, MA, USA.
Lau H; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.
Xavier R; Broad Institute, Cambridge, MA, USA.
Ananthakrishnan AN; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.

Inflamm Bowel Dis ; 2023 Nov 24.

Article em En | MEDLINE | ID: mdl-38001042

Smoking is a key environmental risk factor for the development of inflammatory bowel disease. Smoking induces changes differential epigenetic changes in the peripheral blood in Crohn's disease and ulcerative colitis. Smoking also induces down regulation of expression of various proinflammatory genes in the colon in ulcerative colitis.

Palavras-chave

Crohn's disease; RNA-seq; epigenetics; methylation; smoking; ulcerative colitis

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Inflamm Bowel Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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