Longitudinal evaluation of serum MOG-IgG titers in MOGAD after initiation of maintenance immunoglobulin: A case series.
Mult Scler
; 30(4-5): 594-599, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38018493
ABSTRACT
BACKGROUND:
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a distinct demyelinating disease of the central nervous system. Immunoglobulin (Ig) has been used as a maintenance therapy to prevent relapses in MOGAD, but the impact of Ig on serum MOG-IgG titers is unclear.OBJECTIVE:
To characterize the variation in serum MOG-IgG titers after initiation of Ig treatment in people with MOGAD.METHODS:
We conducted a retrospective study of 10 patients with a diagnosis of MOGAD and available serum MOG-IgG titers before and after initiation of maintenance Ig treatment.RESULTS:
We found that most of the patients remained MOG-IgG seropositive while on Ig treatment with a reduced or unchanged titer, despite a lack of disease activity.CONCLUSIONS:
This case series suggests that the mechanism of action of Ig therapy in MOGAD is not exclusively dependent on MOG-IgG titer reduction.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Pesquisa
/
Cognição
Limite:
Humans
Idioma:
En
Revista:
Mult Scler
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos