Spontaneous regression of recurrent pulmonary large cell neuroendocrine carcinoma with alteration of PD-L1 expression after surgical resection: A case report.
Thorac Cancer
; 15(3): 266-270, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38057657
ABSTRACT
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive subtype of non-small cell lung cancer with a poor prognosis. Spontaneous regression, that is, partial or complete disappearance of a malignancy without medical intervention, is extremely rare in LCNEC. Herein, we present a case of spontaneous complete regression in a 71-year-old male patient with recurrent LCNEC after surgical resection. The patient was diagnosed with stage IB LCNEC and underwent surgical resection. At 1-year follow-up, chest computed tomography revealed a recurrent lesion next to the stump site and enlargement of lymph nodes 4R and 7; recurrent LCNEC was confirmed. The patient declined chemoradiation therapy. One year after recurrence, the patient experienced severe multifocal necrotizing pneumonia and was treated with antibiotics, resulting in a gradual decrease in the size of the recurrent lesion. Five years after the initial diagnosis, positron emission tomography/computed tomography revealed no hypermetabolic lesions, indicating the spontaneous complete regression of LCNEC.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma Neuroendócrino
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Carcinoma de Células Grandes
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Carcinoma Pulmonar de Células não Pequenas
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Neoplasias Pulmonares
Limite:
Aged
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Humans
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Male
Idioma:
En
Revista:
Thorac Cancer
Ano de publicação:
2024
Tipo de documento:
Article