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ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging.
Snieckute, Goda; Ryder, Laura; Vind, Anna Constance; Wu, Zhenzhen; Arendrup, Frederic Schrøder; Stoneley, Mark; Chamois, Sébastien; Martinez-Val, Ana; Leleu, Marion; Dreos, René; Russell, Alexander; Gay, David Michael; Genzor, Aitana Victoria; Choi, Beatrice So-Yun; Basse, Astrid Linde; Sass, Frederike; Dall, Morten; Dollet, Lucile Chantal Marie; Blasius, Melanie; Willis, Anne E; Lund, Anders H; Treebak, Jonas T; Olsen, Jesper Velgaard; Poulsen, Steen Seier; Pownall, Mary Elizabeth; Jensen, Benjamin Anderschou Holbech; Clemmensen, Christoffer; Gerhart-Hines, Zach; Gatfield, David; Bekker-Jensen, Simon.
Afiliação
  • Snieckute G; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Ryder L; Center for Gene Expression, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Vind AC; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Wu Z; Center for Gene Expression, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Arendrup FS; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Stoneley M; Center for Gene Expression, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Chamois S; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Martinez-Val A; Center for Gene Expression, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Leleu M; Biotech Research and Innovation Center, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Dreos R; MRC Toxicology Unit, University of Cambridge, Cambridge CB2 1QR, UK.
  • Russell A; Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland.
  • Gay DM; Mass Spectrometry for Quantitative Proteomics, Proteomics Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
  • Genzor AV; Bioinformatics Competence Center, Ecole Polytechnique Fédérale de Lausanne and University of Lausanne, CH-1015 Lausanne, Switzerland.
  • Choi BS; Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland.
  • Basse AL; Department of Biology, University of York, York YO10 5DD, UK.
  • Sass F; Biotech Research and Innovation Center, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Dall M; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Dollet LCM; Center for Gene Expression, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Blasius M; Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Willis AE; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Lund AH; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Treebak JT; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Olsen JV; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Poulsen SS; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Pownall ME; Center for Gene Expression, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Jensen BAH; MRC Toxicology Unit, University of Cambridge, Cambridge CB2 1QR, UK.
  • Clemmensen C; Biotech Research and Innovation Center, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Gerhart-Hines Z; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Gatfield D; Mass Spectrometry for Quantitative Proteomics, Proteomics Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.
  • Bekker-Jensen S; Department of Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Science ; 382(6675): eadf3208, 2023 12 08.
Article em En | MEDLINE | ID: mdl-38060659
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ribossomos / Estresse Fisiológico / Envelhecimento / Espécies Reativas de Oxigênio / MAP Quinase Quinase Quinase 3 / Obesidade Limite: Animals Idioma: En Revista: Science Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Dinamarca
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ribossomos / Estresse Fisiológico / Envelhecimento / Espécies Reativas de Oxigênio / MAP Quinase Quinase Quinase 3 / Obesidade Limite: Animals Idioma: En Revista: Science Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Dinamarca