Human exposure to diesel exhaust induces CYP1A1 expression and AhR activation without a coordinated antioxidant response.

Friberg, M; Behndig, A F; Bosson, J A; Muala, Ala; Barath, S; Dove, R; Glencross, D; Kelly, F J; Blomberg, A; Mudway, I S; Sandström, T; Pourazar, J

Friberg, M; Behndig, A F; Bosson, J A; Muala, Ala; Barath, S; Dove, R; Glencross, D; Kelly, F J; Blomberg, A; Mudway, I S; Sandström, T; Pourazar, J.

Afiliação

Friberg M; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Behndig AF; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Bosson JA; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Muala A; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Barath S; Department of Respiratory Medicine and Allergy, Lund University Hospital, Lund, Sweden.
Dove R; Wolfson Institute for Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Glencross D; MRC Centre for Environment and Health, Imperial College London, London, UK.
Kelly FJ; NIHR Health Protection Research Unit in Environmental Exposures and Health, Imperial College London, London, UK.
Blomberg A; MRC Centre for Environment and Health, Imperial College London, London, UK.
Mudway IS; NIHR Health Protection Research Unit in Environmental Exposures and Health, Imperial College London, London, UK.
Sandström T; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Pourazar J; MRC Centre for Environment and Health, Imperial College London, London, UK.

Part Fibre Toxicol ; 20(1): 47, 2023 Dec 08.

Article em En | MEDLINE | ID: mdl-38062420

Assuntos

Antioxidantes; Receptores de Hidrocarboneto Arílico; Animais; Humanos; Receptores de Hidrocarboneto Arílico/genética; Receptores de Hidrocarboneto Arílico/metabolismo; Emissões de Veículos/toxicidade; Citocromo P-450 CYP1A1; Fator 2 Relacionado a NF-E2/metabolismo; Epóxido Hidrolases; Xenobióticos; Peptídeos

Palavras-chave

Aryl hydrocarbon receptor; Diesel exhaust; Immunohistochemistry; Oxidative stress; Xenobiotic metabolism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Hidrocarboneto Arílico / Antioxidantes Limite: Animals / Humans Idioma: En Revista: Part Fibre Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suécia

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